The Saluda River originates from headwaters in northern Pickens and Greenville Counties from three primary headwater tributaries: the South Saluda near Table Rock, the Middle Saluda near Caesar’s Head and Jones Gap, and the North Saluda River above Poinsett Reservoir. Table Rock and Poinsett Reservoirs provide drinking water to the greater Greenville area. The three branches join above Saluda Lake, a drinking water source for Easley situated just northwest of Greenville.

The Saluda River flows from the dam at Saluda Lake downstream to the Piedmont dam, the Upper and Lower Pelzer dams, the Lee Steam Diversion Weir, the Holiday dam, and finally the Ware Shoals dam before joining with the Reedy River and Rabon Creek at Lake Greenwood. In addition to hydropower, the Saluda River supplies drinking water to Belton and Honea Path. Lake Rabon and Lake Greenwood are also drinking water sources.

The Saluda River and its tributaries flow through Greenville, Pickens, Anderson, Laurens, Abbeville, and Greenwood Counties and include the Cities of Travelers Rest, Greenville, Easley, Mauldin, Simpsonville, Williamston, Honea Path, and Ware Shoals.